2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P4107
    Bilaid C 2393866-13-0 98%
    Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (Ki=210 nM, hMOPr).
    Bilaid C
  • HY-P4127
    M65 1872440-65-7 98%
    M65 is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches.
    M65
  • HY-P4182
    Schistoflrfamide 121801-61-4 98%
    Schistoflrfamide, a FMRFamide-related peptide, is an inhibitory neuropeptide. Schistoflrfamide decreases the amplitude and frequency of myogenic contractions and reduce basal tension visceral muscle.
    Schistoflrfamide
  • HY-P4196
    Met-Enkephalin-Arg-Phe 73024-95-0 98%
    Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity.
    Met-Enkephalin-Arg-Phe
  • HY-P4223
    Acetyl neurotensin (8-13) 74853-69-3 98%
    Acetyl neurotensin (8-13) is the shortest analog of neurotensin with full binding and pharmacological activities.
    Acetyl neurotensin (8-13)
  • HY-P4281
    Ovotransferrin (328-332) 1226776-54-0 98%
    Ovotransferrin (328-332) has a protective activity on the blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE), with the IC50 of 20 μM. Ovotransferrin (328-332) fragment has an activity against Cholinesterase (ChE), implicating in Alzheimer’s diseases.
    Ovotransferrin (328-332)
  • HY-P4308
    Z-Pro-Pro-aldehyde-dimethyl acetal 170116-63-9 98%
    Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease.
    Z-Pro-Pro-aldehyde-dimethyl acetal
  • HY-P4376
    Gamma-Glu-Abu 16869-42-4 98%
    Gamma-Glu-Abu is an agonist for calcium sensing receptor (CaSR), that activates the CaSR with an EC50 of 0.21 μM in HEK-293 cell.
    Gamma-Glu-Abu
  • HY-P4391
    (Asp37)-Amyloid β-Protein (1-42) 1875128-79-2 98%
    (Asp37)-Amyloid β-Protein (1-42) is the G37D mutant of wild-type Amyloid-beta (1-42) peptide.
    (Asp37)-Amyloid β-Protein (1-42)
  • HY-P4414
    (Des-Bromo)-Neuropeptide B (1-23) (human) 434897-64-0 98%
    (Des-Bromo)-Neuropeptide B (1-23) (human) is an orphan G-protein coupled receptor agonist with Kis of 1.2 nM and 341 nM for GPR7 (NPBW1) and GPR8 (NPBW2), respectively.
    (Des-Bromo)-Neuropeptide B (1-23) (human)
  • HY-P4531
    H-Ser-Tyr-OH 21435-27-8 98%
    H-Ser-Tyr-OH is a dipeptide consisting of glutamic acid, glycine and histidine. H-Ser-Tyr-OH can form a copper(II) complex with copper ions to form a strong free radical scavenging activity. H-Ser-Tyr-OH also increases the intracellular uptake of the delta opioid receptor ligand deltorphin.
    H-Ser-Tyr-OH
  • HY-P4532
    Ac-Leu-Val-Lys-Aldehyde 147600-40-6 98%
    Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II.
    Ac-Leu-Val-Lys-Aldehyde
  • HY-P4555
    (D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide 340821-13-8 98%
    (D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) is a somatostatin analog with Kds of 0.61, 11.05, 23.5, 1200 and >1000 nM for SSTR5, SSTR3, SSTR2, SSTR1 and SSTR4, respectively.
    (D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide
  • HY-P4585
    (Gln22)-Amyloid β-Protein (1-42) 147335-12-4 98%
    (Gln22)-Amyloid β-Protein (1-42) is a Dutch mutation (E22Q) form of β-Amyloid (1-42) (HY-P1363). (Gln22)-Amyloid β-Protein (1-42) exhibits enhanced fibrillogenic and pathogenic properties.
    (Gln22)-Amyloid β-Protein (1-42)
  • HY-P4623
    Penta-alanine 10183-34-3 98%
    Penta-alanine (Penta-L-alanine) is a petide. Penta-alanine can be used for neurological disease research.
    Penta-alanine
  • HY-P4640
    (Lys22)-Amyloid β-Protein (1-42) 383200-59-7 98%
    (Lys22)-Amyloid β-Protein (1-42) is a mutation of WT Amyloid β-Protein (1-42) peptide.
    (Lys22)-Amyloid β-Protein (1-42)
  • HY-P4679
    (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) 103613-84-9 98%
    (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) (E-2078), a stable Dynorphin A (1–8) (HY-P2159) analog, is a kappa opioid receptor (KOR) agonist.
    (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)
  • HY-P4695
    (Thr(PO3H2)231)-Tau Peptide (225-237) 1670270-09-3 98%
    (Thr(PO3H2)231)-Tau Peptide (225-237) is a fragment of tau peptide.
    (Thr(PO3H2)231)-Tau Peptide (225-237)
  • HY-P4708
    Excitin 1 17136-25-3 98%
    Excitin 1 is an orally active and CNS-penetrated peptide, alters behavior and brain monoamine and amino acid concentrations in rats.
    Excitin 1
  • HY-P4709
    (Trp7,β-Ala8)-Neurokinin A (4-10) 132041-95-3 98%
    (Trp7,β-Ala8)-Neurokinin A (4-10) is a potent neurokinin-3 (NK3) antagonist.
    (Trp7,β-Ala8)-Neurokinin A (4-10)
Cat. No. Product Name / Synonyms Application Reactivity